Jian(Felix) Guo

Richelieu Avenue, · Vancouver · (780) 236-1588 · guojiansbox@gmail.com

Analytical Chemistry & Biochemistry

Liquid Chromatography & Mass Spectrometry

Metabolomics & System biology

Bioinformatics & programming (R, Python)

Education

University of British Columbia

Doctor of Philosophy(Ph.D.)
Analytical Chemistry - Bioinformatics and metabolomics

Development of data acquisition mode, development of bioinformatic tools for metabolic feature extraction and evaluation, single cell omics. (Advisor: Dr. Tao Huan)

September 2018 - December 2022

University of Alberta

Master of Science(M.S.)
Chemical Engineering

Design, synthesis, characterization of a new pH-responsive copolymer and its application in oil sands tailings treatment.

September 2012 - December 2014

Zhejiang University

Bachelor of Science(B.S.)
Materials Engineering

Waste water treatment utilizing an innovative thermal-responsive polymer flocculant.

September 2008 - June 2012

Publications

First-author publications

1. Guo, Jian; Yu, H.; Xing, S.;Huan, T., Addressing big data challenges in mass spectrometry-based metabolomics. Chemical Communications, 2022, Feature Article. Publication link

2. Guo, Jian; Shen, S.; Huan, T., Paramounter: Direct Measurement of Universal Parameters to Process Metabolomics Data in a “White Box”. Analytical Chemistry, 2022, 94 (10), 4260-4268. Publication link

3. Guo, Jian; Shen, S.; Liu, M.; Wang, C.; Low, B.; Chen, Y.; Hu, Y.; Xing, S.; Yu, H.; Gao, Y.; Fang, M.; Huan, T., JPA: Joint Metabolic Feature Extraction Increases the Depth of Chemical Coverage for LC-MS-Based Metabolomics and Exposomics. Metabolites, 2022, 12 (3), 212. Publication link

4. Guo, Jian; Huan, T., Turning Metabolomics Data Processing from a “Black Box” to a “White Box”. LCGC, 2022, Feature Article. Publication link

5. Guo, Jian; Shen, S.; Xing, S.; Chen, Y.; Chen, F.; Porter, E.; Yu, H.; Huan, T., EVA: Evaluation of Metabolic Feature Fidelity Using a Deep Learning Model Trained with Over 25000 Extracted Ion Chromatograms. Analytical Chemistry, 2021, 93 (36), 12181-12186. Publication link

6. Guo, Jian; Shen, S.; Xing, S.; Yu, H.; Huan, T., ISFrag: De Novo Recognition of In-Source Fragments for Liquid Chromatography-Mass Spectrometry Data. Analytical Chemistry, 2021, 93 (29), 10243-10250. Publication link

7. Guo, Jian; Shen, S.; Xing, S.; Huan, T., DaDIA: Hybridizing Data-Dependent and Data-Independent Acquisition Modes for Generating High-Quality Metabolomic Data. Analytical Chemistry, 2021, 93 (4), 2669-2677. Publication link

8. Guo, Jian; Huan, T., Comparison of Full-Scan, Data-Dependent, and Data-Independent Acquisition Modes in Liquid Chromatography-Mass Spectrometry Based Untargeted Metabolomics. Analytical Chemistry, 2020, 92 (12), 8072-8080. Publication link

9. Guo, Jian; Huan, T., Evaluation of Significant Features Discovered from Different Data Acquisition Modes in Mass Spectrometry-based Untargeted Metabolomics. Analytica Chimica Acta, 2020, 1137, 37-46. Publication link

10. Guo, Jian; Li, Z.; Li, Y.; Liu, Q.; Yan, C.; Xu, Z., Synthesis and characterization of tunable dual pH-switchable zwitterionic copolymers. Macromolecular Chemistry and Physics, 2016, 217: 1614-1619. Publication link

Co-author publications

1. Nierves, L.; Guo, Jian; Chen, S.; Tsui, J.; Uzozie, A.; Bush, J.; Huan, T.; Lange, P., Multi-omic profiling of the leukemic microenvironment shows bone marrow interstitial fluid is distinct from peripheral blood plasma. Experimental Hematology & Oncology, 2022, . Publication link

2. Oh, T. G.; Kim, S. M.; Caussy, C.; Fu, T.; Guo, Jian; Bassirian, S.; Singh, S.; Madamba, E. V.; Bettencourt, R.; Richards, L.; Yu, R. T.; Atkins, A. R.; Huan, T.; Brenner, D. A.; Sirlin, C. B.; Downes, M.; Evans, R. M.; Loomba, R., A Universal Gut-Microbiome-Derived Signature Predicts Cirrhosis. Cell Metabolism, 2020, 32 (5), 878-888.e6. Publication link

3. Chen, Y.; Guo, Jian; Xing, S.; Yu, H.; Huan, T., Global-Scale Metabolomic Profiling of Human Hair for Simultaneous Monitoring of Endogenous Metabolome, Short- and Long-Term Exposome. Frontiers in chemistry, 2021, 217: 1614-1619. Publication link

4. Dong, Y.; Arif, A. A.; Guo, Jian; Ha, Z.; Lee-Sayer, S. S. M.; Poon, G. F. T.; Dosanjh, M.; Roskelley, C. D.; Huan, T.; Johnson, P., CD44 Loss Disrupts Lung Lipid Surfactant Homeostasis and Exacerbates Oxidized Lipid-Induced Lung Inflammation. Frontiers in Immunology, 2020, 11 (29). Publication link

5. Tang, X.; Kudo, Y.; Baker, J. L.; LaBonte, S.; Jordan, P. A.; McKinnie, S. M. K.; Guo, Jian; Huan, T.; Moore, B. S.; Edlund, A., Cariogenic Streptococcus mutans Produces Tetramic Acid Strain-Specific Antibiotics That Impair Commensal Colonization. ACS Infectious Diseases, 2020, 6 (4), 563-571.6. Publication link

6. Ren, T.; Mao, Z.; Guo, Jian; Gao, C., Directional migration of vascular smooth muscle cells guided by a molecule weight gradient of poly(2-hydroxyethyl methacrylate) brushes. Langmuir, 2013, 29: 6386-6395. Publication link

Awards & Scholarship

  • 1. ASMS Graduate Student Travel Award (20 winners globally), American Society for Mass Spectrometry, 2022
  • 2. Dr. Arnold Travel Fellowship, University of British Columbia, 2022
  • 3. Arthur S. Hawkes Scholarship in Chemistry (2 winners), University of British Columbia, 2021
  • 4. Chemistry Award for Graduate Research Excellence (10 winners in the department of chemistry), University of British Columbia, 2021
  • 5. NSERC Doctoral Scholarship (60 winners nationally), University of British Columbia, 2020 - 2023
  • 6. Four Year Fellowships (FYF) For PhD Students, University of British Columbia, 2020 - 2023
  • 7. Gladys Estella Laird Research Fellowship, University of British Columbia, 2020 - 2023
  • 8. President's Academic Excellence Initiative PhD Award, University of British Columbia, 2020 - 2023
  • 9. Captain Thomas Farrell Greenhalgh Memorial Graduate Scholarship, University of Alberta, 2012
  • 10. National Scholarship (top 1% students), Education Ministry, 2009

Conferences

Presentations

1. Comparison of Data Acquisition Modes in Mass Spectrometry-Based Untargeted Metabolomics in ASMS annual conference 2020.

2. Enhancing Densification by pH-switchable Polymer for Tailings Treatment in Paste annual conference 2014.

Posters

1. Processing Metabolomics Data in a "White Box" via Direct Measurement of Universal Parameters in ASMS annual conference 2022.

Leadership & Interests

  • An enthusiastic instructor teaching undergraduate courses including Analytical Chemistry, Biochemistry, and Biology, receiving consecutive 4 years of top evaluation (4.95/5.0).
  • A department safety and first aid representative performing monthly lab safety inspection and annual safety training, having done CPR on 2 students.
  • A graduate recruiting committee member organizing campus and lab tours for the visiting students.
  • A graduate student panel member in the undergraduate research conference and mentor in CDI(Chemists for Diversity and Inclusion), inspiring the undergrad studnets by providing constructive feedback on their research projects.
  • A project leader coordinating with mechanical and financial department, and implementing a whole set of equipment for bitumen extraction in 2 weeks at AdvEn Industries in 2016.
  • A client advisor managing broad clientele at Louis Vuitton in 2017.
  • When outdoors, I am a keen eater of various cuisines and food blogger. When forced indoors, I am an aspiring chef.
  • Global traveller eager to experience different cultures and customs.